Suggested Rational Considerations for ANA-IF and ENA-Profile Test Requisition: Clinical Manifestation, Gender, Pattern, and Titer of ANA-IF
نویسندگان
چکیده
BACKGROUND: The anti-nuclear antibody immunofluorescence (ANA-IF) test is used for screening of autoantibody presence in patients with suspected autoimmune disease. Positive ANA-IF should be followed-up extractable nuclear antigens profile (ENA-profile). High sensitivity combined low ENA-profile sensitivity, and the evolution requests may result a higher number positive but negative ENA-profile. It necessary to make an objective assessment determining conditions which rational suggested.METHODS: Data were retrieved retrospectively from medical records subjects who performed both examined using principle cut-off 1:100. contained sixteen purified was line-immunoblot principle. analyzed descriptively analytically SPSS, significant indicated if p<0.05.RESULTS: dominated by (44.9%) positive-speckled, titer 1:100 (32.9%). Of 923 ANA-IF, 45.4% had 751 10.2% In whose specific clinical entity, predictive value (NPV) detecting 93.8% 93.3%, respectively, (PPV) 63.2%. Women manifestation accompanied homogeneous ≥1:100, or centromeres speckled ≥1:320 might have been predicted as subsequent area under curve (AUC) 77.2%, 76.9%, 79.2%, respectively.CONCLUSION: only those symptoms. For woman typical symptoms, further ENA-profile.KEYWORDS: ENA-profile, autoimmune,
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ژورنال
عنوان ژورنال: The Indonesian Biomedical Journal
سال: 2023
ISSN: ['2355-9179', '2085-3297']
DOI: https://doi.org/10.18585/inabj.v15i3.2346